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Construction of Substituted N ‐Hydroxyindoles: Synthesis of a Nocathiacin I Model System
Author(s) -
Nicolaou K. C.,
Lee Sang Hyup,
Estrada Anthony A.,
Zak Mark
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200500724
Subject(s) - nitrone , structural motif , molecule , chemistry , stereochemistry , combinatorial chemistry , organic chemistry , biochemistry , cycloaddition , catalysis
Generation (1→2) and trapping (2→3) of the fleeting α,β‐unsaturated nitrone system 2 leads to the rare, biologically important N ‐hydroxyindole 3 in synthetically useful yields. This structural motif is found within the molecule of the antibiotic nocathiacin I.