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Cellular Profiling of Small‐Molecule Bioactivities: an Alternative Tool for Chemical Biology
Author(s) -
Berg Thorsten
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200500721
Subject(s) - profiling (computer programming) , computational biology , phenotype , small molecule , chemical biology , chemical genetics , identification (biology) , phenotypic screening , biology , computer science , chemistry , genetics , gene , ecology , operating system
Are they a good match? Target identification is critical to the success of chemical genetics projects that start with phenotypic screens. The method highlighted herein is a novel way to decrease the number of potential biological targets of compounds identified in phenotypic screens by comparison of their cellular activity profiles with those obtained with reference compounds. Activity profiles for hypothetical compounds A and B are shown.