Total Synthesis of Halipeptins A and D and Analogues | Zendy

Nicolaou K. C. | Zendy; Kim David W. | Zendy; Schlawe Daniel | Zendy; Lizos Dimitrios E. | Zendy; de Noronha Rita G. | Zendy; Longbottom Deborah A. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Total Synthesis of Halipeptins A and D and Analogues

Author(s) -

Nicolaou K. C.,

Kim David W.,

Schlawe Daniel,

Lizos Dimitrios E.,

de Noronha Rita G.,

Longbottom Deborah A.

Publication year - 2005

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200500702

Subject(s) - thiazoline , chemistry , peptide , sulfur , stereochemistry , ring (chemistry) , biochemistry , organic chemistry

Deceptive rings : Halipeptins A ( 1 a ) and D ( 1 b ) and analogues thereof were synthesized from fragments 2 and 3 a, b , respectively. Key steps included peptide‐bond formation, DAST‐induced thiazoline construction, and macrolactamization. Unlike the naturally isolated (and possibly contaminated) material, synthetic 1 b exhibited only weak toxicity against tumor cells. DAST=(diethylamino)sulfur trifluoride.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research