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A Labeled Neutral Endopeptidase Inhibitor as a Potential Tool for Tumor Diagnosis and Prognosis
Author(s) -
Raguin Olivier,
FourniéZaluski MarieClaude,
Romieu Anthony,
Pèlegrin André,
Chatelet François,
Pélaprat Didier,
Barbet Jacques,
Roques Bernard P.,
GruazGuyon Anne
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200500700
Subject(s) - neprilysin , in vivo , chemistry , endopeptidase , enzyme , cancer research , biochemistry , medicine , biology , microbiology and biotechnology
Specific targeting of tumors with radioactive isotopes is the key for high‐sensitivity scintigraphy detection. A labeled neutral endopeptidase (NEP) inhibitor is described that accumulates in vivo in tumor cells expressing this enzyme, which makes it a potential tool for noninvasive evaluation of NEP expression. Its structure (black with the label depicted in red, DTPA=diethylenetriaminepentaacetic acid) is shown in a model of the NEP active site (blue).