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Structurally Simple Farnesyltransferase Inhibitors Arrest the Growth of Malaria Parasites
Author(s) -
Glenn Matthew P.,
Chang SungYoun,
Hucke Oliver,
Verlinde Christophe L. M. J.,
Rivas Kasey,
Hornéy Carrie,
Yokoyama Kohei,
Buckner Frederick S.,
Pendyala Prakash R.,
Chakrabarti Debopam,
Gelb Michael,
Van Voorhis Wesley C.,
Sebti Saïd M.,
Hamilton Andrew D.
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200500674
Subject(s) - farnesyltransferase , malaria , plasmodium falciparum , simple (philosophy) , computational biology , computer science , chemistry , combinatorial chemistry , biology , biochemistry , immunology , enzyme , philosophy , prenylation , epistemology
Antimalarial compounds: Structurally simple acyclic inhibitors of protein farnesyltransferase (active‐site model shown) from the malaria parasite Plasmodium falciparum may allow third world countries access to an effective and inexpensive antimalarial therapy to counter the estimated half billion infections that occur annually.