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The Thermal Unfolding of Native Cytochrome c in the Transition from Solution to Gas Phase Probed by Native Electron Capture Dissociation
Author(s) -
Breuker Kathrin,
McLafferty Fred W.
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200500668
Subject(s) - intramolecular force , dehydration , dissociation (chemistry) , gas phase , chemistry , phase transition , electron , chemical physics , thermal , cytochrome c , crystallography , thermodynamics , stereochemistry , physics , biochemistry , nuclear physics , mitochondrion
Unfolding upon dehydration:. What happens to the structure of a native protein that is suddenly exposed to vacuum? Native electron capture dissociation shows that dehydration turns the strongest intramolecular interactions in solution into the weakest in the gas phase.