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Recent Progress in Asymmetric Allylic Substitutions Catalyzed by Chiral Copper Complexes
Author(s) -
Yorimitsu Hideki,
Oshima Koichiro
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200500653
Subject(s) - nucleophile , catalysis , allylic rearrangement , copper , palladium , regioselectivity , reagent , combinatorial chemistry , chemistry , organic chemistry
Copper complements palladium as a catalyst of asymmetric allylic substitutions (see scheme). Palladium catalysis requires soft nucleophiles to ensure high stereo‐ and regioselectivity, whereas hard nucleophiles such as Grignard and organozinc reagents may be used under copper catalysis. Vast progress during the last decade reveals the promising future of copper catalysis in this asymmetric transformation.