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DNA Microarrays as Decoding Tools in Combinatorial Chemistry and Chemical Biology
Author(s) -
Lovrinovic Marina,
Niemeyer Christof M.
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200500645
Subject(s) - dna microarray , nucleic acid , computational biology , dna , profiling (computer programming) , chemistry , decoding methods , combinatorial chemistry , chemical biology , biology , computer science , microbiology and biotechnology , biochemistry , gene , algorithm , gene expression , operating system
Decoding technology : Besides mainstream applications in transcription profiling, DNA microarrays are currently being explored as tools for the deconvolution of synthetic libraries. Current examples include the discovery of a new type of organic reaction and the screening of peptide nucleic acid encoded inhibitor libraries to investigate new proteolytic activities from dust mite extracts (see picture).