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Multivalent Peptide and Protein Dendrimers Using Native Chemical Ligation
Author(s) -
van Baal Ingrid,
Malda Hinke,
Synowsky Silvia A.,
van Dongen Joost L. J.,
Hackeng Tilman M.,
Merkx Maarten,
Meijer E. W.
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200500635
Subject(s) - dendrimer , native chemical ligation , peptide , modular design , combinatorial chemistry , chemistry , cysteine , computational biology , nanotechnology , computer science , biochemistry , biology , materials science , programming language , enzyme
A wide variety of well‐defined multivalent peptides and proteins can be made by conjugating synthetic peptides and recombinantly expressed proteins to cysteine‐functionalized dendrimers using native chemical ligation (see picture). This modular approach provides access to dendrimers that are attractive both for understanding fundamental issues of multivalency in biological interactions as well as for biomedical applications.