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Regio‐ and Stereoselective Approach to 1,2‐Di‐ and 1,1,2‐Trisilylethenes by Cobalt‐Mediated Reaction of Silyl‐Substituted Dibromomethanes with Silylmethylmagnesium Reagents
Author(s) -
Ohmiya Hirohisa,
Yorimitsu Hideki,
Oshima Koichiro
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200500576
Subject(s) - silylation , reagent , stereoselectivity , regioselectivity , chemistry , cobalt , stoichiometry , catalysis , transformation (genetics) , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry , gene , biochemistry
Functional ethenes : Treatment of dibromo(silyl)methanes 2 a with silylmethyl Grignard reagents 1 and catalytic CoCl 2 affords ( E )‐1,2‐disilylethenes 3 a in excellent yields. Dibromodisilylmethanes 2 b undergo a similar transformation to furnish trisilylethenes 3 b with excellent stereo‐ and regioselectivity in the presence of a stoichiometric amount of a cobaltate reagent.