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Strategies for Catalytic Asymmetric Electrophilic α Halogenation of Carbonyl Compounds
Author(s) -
Oestreich Martin
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200500478
Subject(s) - enantioselective synthesis , halogenation , electrophile , catalysis , halogen , chemistry , organic synthesis , combinatorial chemistry , halogen bond , organic chemistry , alkyl
Mission possible: Today, catalytic asymmetric variants of nearly all fundamental bond‐forming reactions are known, yet catalyst‐controlled enantioselective construction of carbon–halogen bonds (see scheme; X=F, Cl, Br) was still missing. This gap has now been filled by a cornucopia of conceptually diverse approaches that provide a novel tool for asymmetric organic synthesis.