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A Dendritic Tetra(bisphosphonic acid) for Improved Targeting of Proteins to Bone
Author(s) -
Bansal Geeti,
Wright Jennifer E. I.,
Kucharski Cezary,
Uludaǧ Hasan
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200500350
Subject(s) - tetra , molecule , chemistry , biochemistry , organic chemistry , medicinal chemistry
Close to the bone : A dendritic molecule that contains four bone‐seeking bisphosphonic acid groups (see picture) has been prepared for targeting proteins to bone tissue. The tetra(bisphosphonic acid) molecule provides a high density of bisphosphonic acid groups per attachment site at the protein and will aid the design of bone‐seeking proteins with minimal modification.