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An Artificial Riboflavin Receptor Prepared by a Template Analogue Imprinting Strategy
Author(s) -
Manesiotis Panagiotis,
Hall Andrew J.,
Courtois Julien,
Irgum Knut,
Sellergren Börje
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200500342
Subject(s) - riboflavin , isothermal microcalorimetry , receptor , chemistry , population , hydrogen bond , molecular imprinting , combinatorial chemistry , biochemistry , organic chemistry , selectivity , physics , molecule , thermodynamics , medicine , environmental health , enthalpy , catalysis
Cheers! Specificity for riboflavin in water‐rich media with an affinity on the order found for the corresponding biological receptor, riboflavin binding protein, is shown by a receptor containing a complementary hydrogen bonding array (see picture). Microcalorimetry performed at low receptor concentrations in a solution mimicking an alcoholic beverage indicated the presence of a small but uniform population of high‐affinity sites ( K >10 6 M −1 ).