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DNA‐Based Asymmetric Catalysis
Author(s) -
Roelfes Gerard,
Feringa Ben L.
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200500298
Subject(s) - dna , catalysis , chirality (physics) , twist , chemistry , stereochemistry , product (mathematics) , combinatorial chemistry , biochemistry , physics , mathematics , particle physics , nambu–jona lasinio model , quark , chiral symmetry breaking , geometry
A twist in catalysis! The chirality of DNA is transferred directly to a Diels–Alder reaction by using a DNA‐tethered catalyst. A catalytically active copper complex with achiral ligands self‐assembles with DNA to give products with up to 90 % ee , as is the case for the exo isomer of product 1 .
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