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Dihydroxyacetone in Amino Acid Catalyzed Mannich‐Type Reactions
Author(s) -
Westermann Bernhard,
Neuhaus Christiane
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200500297
Subject(s) - dihydroxyacetone , mannich reaction , catalysis , chemistry , solvent , organic chemistry , proline , amino acid , medicinal chemistry , biochemistry , glycerol
The C 3 equivalent dihydroxyacetone was used in its protected form in proline‐catalyzed Mannich reactions (see scheme). As little as 5 mol % catalyst is required when using 2,2,2‐trifluoroethanol as solvent. The reaction is improved further (reaction time 10 min) under microwave conditions. PMP= p ‐methoxyphenyl.
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