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Studies toward the Synthesis of Azadirachtin, Part 2: Construction of Fully Functionalized ABCD Ring Frameworks and Unusual Intramolecular Reactions Induced by Close‐Proximity Effects
Author(s) -
Nicolaou K. C.,
Sasmal Pradip K.,
Koftis Theocharis V.,
Converso Antonella,
Loizidou Eriketi,
Kaiser Florian,
Roecker A. J.,
Dellios Constantinos C.,
Sun XiaoWen,
Petrovic Goran
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200500217
Subject(s) - azadirachtin , intramolecular force , total synthesis , ring (chemistry) , chemistry , stereochemistry , combinatorial chemistry , nanotechnology , organic chemistry , pesticide , materials science , biology , ecology
The remarkable antifeedant agent and insecticide, azadirachtin ( 1 ), has, to date, escaped a total synthesis. The preparation of an advanced precursor has revealed some of the inner intricacies of this uniquely crowded and highly functionalized molecular architecture.