Studies toward the Synthesis of Azadirachtin, Part 1: Total Synthesis of a Fully Functionalized ABC Ring Framework and Coupling with a Norbornene Domain | Zendy

Nicolaou K. C. | Zendy; Sasmal Pradip K. | Zendy; Roecker A. J. | Zendy; Sun  XiaoWen | Zendy; Mandal Sunil | Zendy; Converso Antonella | Zendy

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Studies toward the Synthesis of Azadirachtin, Part 1: Total Synthesis of a Fully Functionalized ABC Ring Framework and Coupling with a Norbornene Domain

Author(s) -

Nicolaou K. C.,

Sasmal Pradip K.,

Roecker A. J.,

Sun XiaoWen,

Mandal Sunil,

Converso Antonella

Publication year - 2005

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200500216

Subject(s) - azadirachtin , decalin , norbornene , total synthesis , coupling (piping) , stereochemistry , ring (chemistry) , chemistry , combinatorial chemistry , organic chemistry , materials science , biology , catalysis , polymer , monomer , pesticide , agronomy , metallurgy

The advanced decalin intermediate 1 was synthesized and elaborated into the potential azadirachtin precursor 2 . The challenging synthesis involved several protecting‐group manipulations and coupling of 1 with an appropriate norbornene unit.

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