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Solvent Effect on Crystal Polymorphism: Why Addition of Methanol or Ethanol to Aqueous Solutions Induces the Precipitation of the Least Stable β Form of Glycine
Author(s) -
Weissbuch Isabelle,
Torbeev Vladimir Yu.,
Leiserowitz Leslie,
Lahav Meir
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200500164
Subject(s) - metastability , polymorphism (computer science) , crystallization , solvent , methanol , glycine , aqueous solution , crystal (programming language) , ethanol , molecule , chemistry , precipitation , crystal growth , crystallography , stereochemistry , organic chemistry , amino acid , allele , biochemistry , gene , physics , meteorology , computer science , programming language
Crystallization of the thermodynamically metastable β glycine is explained on the basis of its growth at the opposite poles of the crystal (see graph) and by considering the structure of the relevant surfaces of the three polymorphs and their interactions with solvent molecules.