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Alternate Isotope‐Coded Derivatization Assay: An Isotope Dilution Method Applied to the Quantification of Zearalenone in Maize Flour
Author(s) -
Sforza Stefano,
Dall'Asta Chiara,
Moseriti Alessandra,
Galaverna Gianni,
Dossena Arnaldo,
Marchelli Rosangela
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200500148
Subject(s) - analyte , isotope dilution , zearalenone , chromatography , derivatization , chemistry , reagent , matrix (chemical analysis) , isotope , calibration curve , calibration , dilution , analytical chemistry (journal) , mass spectrometry , detection limit , mathematics , mycotoxin , organic chemistry , food science , physics , statistics , quantum mechanics , thermodynamics
Low‐cost isotope dilution made easy : An alternate reaction of an analyte in a matrix and in a standard solution with isotope‐labeled or unlabeled derivatizing reagents allows quantification of zearalenone in maize flour without the need for a calibration curve. This is possible by direct calculation of the relative response factor for the analyte/internal standard ratio of the sample (see picture).