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Ruthenium‐Catalyzed Reactions—A Treasure Trove of Atom‐Economic Transformations
Author(s) -
Trost Barry M.,
Frederiksen Mathias U.,
Rudd Michael T.
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200500136
Subject(s) - atom economy , ruthenium , reactivity (psychology) , treasure , catalysis , context (archaeology) , atom (system on chip) , chemistry , metathesis , combinatorial chemistry , molecule , biochemical engineering , computer science , nanotechnology , organic chemistry , materials science , polymer , philosophy , engineering , history , medicine , alternative medicine , theology , pathology , polymerization , embedded system , archaeology
The demand for new chemicals spanning the fields of health care to materials science combined with the pressure to produce these substances in an environmentally benign fashion pose great challenges to the synthetic chemical community. The maximization of synthetic efficiency by the conversion of simple building blocks into complex targets remains a fundamental goal. In this context, ruthenium complexes catalyze a number of non‐metathesis conversions and allow the rapid assembly of complex molecules with high selectivity and atom economy. These complexes often exhibit unusual reactivity. Careful consideration of the mechanistic underpinnings of the transformations can lead to the design of new reactions and the discovery of new reactivity.