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Molecular Recognition of Basic Fibroblast Growth Factor by Polyoxometalates
Author(s) -
Wu Qiang,
Wang Ju,
Zhang Ling,
Hong An,
Ren Jinsong
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200500108
Subject(s) - polyoxometalate , basic fibroblast growth factor , fibroblast growth factor , angiogenesis , chemistry , fibroblast growth factor receptor , fgf1 , fibroblast , growth factor , molecular recognition , combinatorial chemistry , biochemistry , molecule , cancer research , biology , organic chemistry , receptor , in vitro , catalysis
Protein binders : Three representative polyoxometalate (POM) compounds, for example 1 , which is of the Wells–Dawson class, were found to interact with the basic fibroblast growth factor (bFGF, right). The binding induces dramatic conformational changes in the growth factor. POMs are promising leads for compounds that may represent a new avenue for the development of therapeutic agents against bFGF‐induced angiogenesis.