Cobalt( II )‐Catalyzed Cross‐Coupling of Polyfunctional Aryl Copper Reagents with Aryl Bromides and Chlorides | Zendy

Korn Tobias J. | Zendy; Knochel Paul | Zendy

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Cobalt( II )‐Catalyzed Cross‐Coupling of Polyfunctional Aryl Copper Reagents with Aryl Bromides and Chlorides

Author(s) -

Korn Tobias J.,

Knochel Paul

Publication year - 2005

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200500099

Subject(s) - aryl , chemistry , reagent , transmetalation , catalysis , palladium , cobalt , coupling reaction , allylic rearrangement , medicinal chemistry , organic chemistry , polymer chemistry , alkyl

Polyfunctionalized biphenyl and heteroaromatic compounds were formed in the presence of [Co(acac) 2 ], Bu 4 NI, and 4‐fluorostyrene ( 3 ) through a smooth cross‐coupling reaction between organocopper reagents 1 , prepared by the transmetalation of functionalized aryl magnesium halides with CuCN⋅2 LiCl, and aryl halides 2 that bear electron‐withdrawing substituents. acac=acetylacetonate, DME=1,2‐dimethoxyethane, DMPU=1,3‐dimethyl‐3,4,5,6‐tetrahydro‐2(1 H )‐pyrimidinone.

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