Premium
Cobalt( II )‐Catalyzed Cross‐Coupling of Polyfunctional Aryl Copper Reagents with Aryl Bromides and Chlorides
Author(s) -
Korn Tobias J.,
Knochel Paul
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200500099
Subject(s) - aryl , chemistry , reagent , transmetalation , catalysis , palladium , cobalt , coupling reaction , allylic rearrangement , medicinal chemistry , organic chemistry , polymer chemistry , alkyl
Polyfunctionalized biphenyl and heteroaromatic compounds were formed in the presence of [Co(acac) 2 ], Bu 4 NI, and 4‐fluorostyrene ( 3 ) through a smooth cross‐coupling reaction between organocopper reagents 1 , prepared by the transmetalation of functionalized aryl magnesium halides with CuCN⋅2 LiCl, and aryl halides 2 that bear electron‐withdrawing substituents. acac=acetylacetonate, DME=1,2‐dimethoxyethane, DMPU=1,3‐dimethyl‐3,4,5,6‐tetrahydro‐2(1 H )‐pyrimidinone.