Premium
A General Strategy toward S‐Linked Glycopeptides
Author(s) -
Thayer Desiree A.,
Yu Henry N.,
Galan M. Carmen,
Wong ChiHuey
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200500090
Subject(s) - glycopeptide , glycosyl , formamide , yield (engineering) , amino acid , combinatorial chemistry , chemistry , organic chemistry , stereochemistry , biochemistry , materials science , metallurgy , antibiotics
A high‐yield one‐pot synthesis of S‐linked glycosyl amino acids 1 has been developed (see scheme; DMF=dimethyl formamide) and used in the solid‐phase synthesis of S‐linked glycopeptides. This approach has been shown to be efficient for the synthesis of various S‐linked glycosyl amino acid building blocks.