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Evidence that Electrostatic Interactions Dictate the Ligand‐Induced Arrest of RNA Global Flexibility
Author(s) -
Pitt Stephen W.,
Zhang Qi,
Patel Dinshaw J.,
AlHashimi Hashim M.
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200500075
Subject(s) - tar (computing) , rna , chemistry , molecule , chemical physics , ligand (biochemistry) , biophysics , molecular dynamics , electrostatics , flexibility (engineering) , dipole , computational chemistry , biochemistry , biology , organic chemistry , receptor , computer science , mathematics , statistics , gene , programming language
The global dynamics of the TAR RNA from HIV‐1 bound to two distinctly charged molecules have been characterized by NMR studies of residual dipolar couplings (see picture). While neomycin B (NeoB: +5) arrests global motions in TAR, the small organic molecule acetylpromazine (AcP: +1) does not. Results indicate that electrostatic interactions are critical for arresting global motions in RNA.