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Assembly of the Complete Eight‐Base Artificial Genetic Helix, xDNA, and Its Interaction with the Natural Genetic System
Author(s) -
Gao Jianmin,
Liu Haibo,
Kool Eric T.
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200500069
Subject(s) - base pair , dna , nucleotide , helix (gastropod) , natural (archaeology) , rna , computational biology , basis (linear algebra) , sequence (biology) , biology , base (topology) , genetics , computer science , gene , stereochemistry , chemistry , mathematics , ecology , paleontology , geometry , snail , mathematical analysis
Expanding DNA : The four natural DNA nucleotides were combined with four benzo‐homologous nucleotides to make self‐assembling double helices (see base‐paired structures). Strands of this “xDNA” form highly stable, sequence‐specific duplexes with native DNA and RNA, and can expand the information capacity of DNA from a basis of four to eight characters.