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Polyethylenimine‐Grafted Multiwalled Carbon Nanotubes for Secure Noncovalent Immobilization and Efficient Delivery of DNA
Author(s) -
Liu Ye,
Wu DeCheng,
Zhang WeiDe,
Jiang Xuan,
He ChaoBin,
Chung Tai Shung,
Goh Suat Hong,
Leong Kam W.
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200500042
Subject(s) - polyethylenimine , dna , carbon nanotube , gene delivery , transfection , nanotechnology , materials science , surface modification , chemical engineering , chemistry , gene , biochemistry , engineering
DNA hits the wall : DNA is immobilized securely onto the surface of multiwalled carbon nanotubes through electrostatic interactions with grafted polyethylenimine (PEI; see picture). The polyethylenimine‐graft multiwalled carbon nanotubes carrying DNA show transfection efficiency for DNA delivery similar to or even several times higher than PEI.