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Molecular Recognition by Glycoside Pseudo Base Pairs and Triples in an Apramycin–RNA Complex
Author(s) -
Han Qing,
Zhao Qiang,
Fish Sarah,
Simonsen Klaus B.,
Vourloumis Dionisios,
Froelich Jamie M.,
Wall Daniel,
Hermann Thomas
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200500028
Subject(s) - ribosome , rna , ribosomal rna , computational biology , base pair , computer science , chemistry , biology , stereochemistry , dna , genetics , gene
In the groove : The crystal structure of the bacterial decoding‐site RNA in a complex with the antibiotic apramycin reveals how glycoside scaffolds participate in RNA recognition by natural products through the formation of pseudo base pairs and triples. The structure suggests that the inhibitory action of apramycin is based on interaction of the antibiotic with ribosomal protein S12 (see structural model), a control element of ribosome translocation.