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Insight into and Practical Application of pH‐Controlled Asymmetric Transfer Hydrogenation of Aromatic Ketones in Water
Author(s) -
Wu Xiaofeng,
Li Xiaoguang,
King Frank,
Xiao Jianliang
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200500023
Subject(s) - transfer hydrogenation , enantioselective synthesis , catalysis , noyori asymmetric hydrogenation , chemistry , organic chemistry , combinatorial chemistry , ruthenium
Much faster , more enantioselective, and more‐productive catalysis was attained in the asymmetric transfer hydrogenation of aromatic ketones with the Noyori–Ikariya Ru–Ts‐dpen catalyst in water under slightly basic conditions (see scheme). At low pH values, the reaction was much less efficient and appears to operate through a different mechanism.