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Cover Picture: Supramolecular Catalysis of a Unimolecular Transformation: Aza‐Cope Rearrangement within a Self‐Assembled Host (Angew. Chem. Int. Ed. 48/2004)
Author(s) -
Fiedler Dorothea,
Bergman Robert G.,
Raymond Kenneth N.
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200490169
Subject(s) - supramolecular chemistry , chemistry , catalysis , cover (algebra) , supramolecular catalysis , ligand (biochemistry) , sigmatropic reaction , hydrolysis , cope rearrangement , stereochemistry , aqueous solution , molecule , receptor , organic chemistry , biochemistry , mechanical engineering , engineering
A supramolecular metal–ligand assembly … catalyzes the [3,3]‐sigmatropic rearrangement of enammonium guests in aqueous solution. The cover picture shows the proposed catalytic cycle. The space‐restrictive host cavity forces the substrates to bind in a reactive chairlike conformation and thus accelerates the rate of rearrangement. Release and hydrolysis of the rearranged product enable catalytic turnover. For more information, see the Communication by R. G. Bergman, K. N. Raymond, and D. Fiedler on p. 6748 ff.