Cover Picture: Chiral Centers in the Side Chains of α‐Amino Acids Control the Helical Screw Sense of Peptides (Angew. Chem. Int. Ed. 40/2004) | Zendy

Tanaka Masakazu | Zendy; Demizu Yosuke | Zendy; Doi Mitsunobu | Zendy; Kurihara Masaaki | Zendy; Suemune Hiroshi | Zendy

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Cover Picture: Chiral Centers in the Side Chains of α‐Amino Acids Control the Helical Screw Sense of Peptides (Angew. Chem. Int. Ed. 40/2004)

Author(s) -

Tanaka Masakazu,

Demizu Yosuke,

Doi Mitsunobu,

Kurihara Masaaki,

Suemune Hiroshi

Publication year - 2004

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Reports

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200490139

Subject(s) - stereocenter , cover (algebra) , helix (gastropod) , stereochemistry , peptide , amino acid , sense (electronics) , chemistry , crystallography , biology , enantioselective synthesis , biochemistry , catalysis , engineering , paleontology , mechanical engineering , snail

A tidal vortex (helix) is formed, both right‐ and left‐handed, where a violent tidal current meets a peaceful sea (the picture from Naruto City Tourist Association shows an example at Naruto channel, Japan). In contrast, α‐helices of proteins almost always show a right‐handed helical screw sense because of the stereogenic α‐carbon center of α‐amino acids. M. Tanaka et al. now demonstrate on page 5360 ff. how the left‐handedness of a α‐helical peptide is controlled by the side‐chain stereogenic centers.

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