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Cover Picture: Total Synthesis and Configurational Assignment of (−)‐Dictyostatin, a Microtubule‐Stabilizing Macrolide of Marine Sponge Origin / Total Synthesis of (−)‐Dictyostatin: Confirmation of Relative and Absolute Configurations (Angew. Chem. Int. Ed. 35/2004)
Author(s) -
Paterson Ian,
Britton Robert,
Delgado Oscar,
Meyer Arndt,
Poullennec Karine G.,
Shin Youseung,
Fournier JeanHugues,
Fukui Yoshikazu,
Brückner Arndt M.,
Curran Dennis P.
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200490122
Subject(s) - total synthesis , sponge , int , microtubule , chemistry , stereochemistry , absolute configuration , cover (algebra) , combinatorial chemistry , biology , microbiology and biotechnology , computer science , mechanical engineering , botany , engineering , operating system
Sponging off nature is a reliable way to find promising drug leads: (−)‐Dictyostatin, which was isolated from the marine sponge Corallistidae , is a novel microtubule‐stabilizing agent that could be useful against multidrug‐resistant tumors. In their Communications on pages 4629 ff. and 4634 ff., the groups of I. Paterson and D. P. Curran describe the total synthesis of this challenging target, thus establishing unequivocally the relative and absolute configuration of the macrolactone and opening the way to useful amounts of the drug and designed analogues. The Photo of the sponge was provided by Harbor Branch Oceanographic Institution.