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Cover Picture: Structural Revision and Total Synthesis of Azaspiracid‐1, Part 1: Intelligence Gathering and Tentative Proposal (Angew. Chem. Int. Ed. 33/2004)
Author(s) -
Nicolaou K. C.,
Vyskocil Stepan,
Koftis Theocharis V.,
Yamada Yoichi M. A.,
Ling Taotao,
Chen David Y.K.,
Tang Wenjun,
Petrovic Goran,
Frederick Michael O.,
Li Yiwei,
Satake Masayuki
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200490111
Subject(s) - total synthesis , marine toxin , cover (algebra) , mytilus , chemistry , stereochemistry , combinatorial chemistry , biology , toxin , ecology , biochemistry , engineering , mechanical engineering
The mussel toxin azaspiracid‐1, which was isolated from Mytilus edulis , has baffled chemists for quite some time, as the originally proposed structure was incorrect. In their Communications on pages 4312 ff. and 4318 ff., Nicolaou and co‐workers describe how they determined the structure and absolute configuration of the molecule through degradation studies and total synthesis. The synthesis should render this valuable, but scarce, substance available for much‐needed biotoxin assays and biological investigations.