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Cover Picture: Excess Electron Transport Through DNA: A Single Electron Repairs More than One UV‐Induced Lesion (Angew. Chem. Int. Ed. 14/2004)
Author(s) -
Giese Bernd,
Carl Barbara,
Carl Thomas,
Carell Thomas,
Behrens Christoph,
Hennecke Ulrich,
Schiemann Olav,
Feresin Emiliano
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200490038
Subject(s) - thymine , pyrimidine dimer , dna , electron transport chain , chemistry , electron , dimer , cover (algebra) , photochemistry , crystallography , stereochemistry , dna damage , physics , biochemistry , organic chemistry , mechanical engineering , quantum mechanics , engineering
Electron‐catalyzed repair of thymine dimers in double‐stranded DNA is described by B. Giese, T. Carell, O. Schiemann, and co‐workers on page 1848 ff. Transport of an electron from a remote modified thymine base through DNA occurs in a multistep hopping process. When the electron meets a thymine dimer, which is generated by photocycloaddition of adjacent thymine residues, the two thymine bases are repaired through a retro‐cyclization reaction, while the electron continues along the DNA.