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Cover Picture: Nontoxic Membrane‐Active Antimicrobial Arylamide Oligomers (Angew. Chem. Int. Ed. 9/2004)
Author(s) -
Liu Dahui,
Choi Sungwook,
Chen Bin,
Doerksen Robert J.,
Clements Dylan J.,
Winkler Jeffrey D.,
Klein Michael L.,
DeGrado William F.
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200490021
Subject(s) - oligomer , amphiphile , antimicrobial , chemistry , octane , cover (algebra) , membrane , combinatorial chemistry , organic chemistry , biochemistry , engineering , copolymer , polymer , mechanical engineering
The amphiphilic nature of a highly selective antimicrobial arylamide oligomer is shown by the simulation of its conformation at a water/octane interface. Arginine end groups make this oligomer the most amphiphilic in the series studied and increase its overall hydrophobic moment. While the former property correlates with its low toxicity, the latter correlates with a high antimicrobial activity. More details are described in the Communication by DeGrado and co‐workers on page 1158 ff.