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Cover Picture: Antifreeze Glycoproteins: Elucidation of the Structural Motifs That Are Essential for Antifreeze Activity (Angew. Chem. Int. Ed. 7/2004)
Author(s) -
Tachibana Yuki,
Fletcher Garth L.,
Fujitani Naoki,
Tsuda Sakae,
Monde Kenji,
Nishimura ShinIchiro
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200490013
Subject(s) - antifreeze , chemistry , glycoprotein , polar , stereochemistry , crystallography , biochemistry , physics , organic chemistry , astronomy
Antifreeze glycoproteins (AFGPs) found in the body fluids of polar fish are known to protect them from freezing by suppressing ice‐crystal growth. The essential structural motifs of AFGPs were revealed by using a combination of chemical synthesis and spectroscopic analysis. The amphiphatic AFGPs form a threefold left‐handed axis, which enables the sugar moieties to cluster on one side of the molecule. For further details see the Communication by S.‐I. Nishimura and co‐workers on page 856 ff.