Total Chemical Synthesis and X‐ray Crystal Structure of a Protein Diastereomer: [ D ‐Gln 35]Ubiquitin | Zendy

Bang Duhee | Zendy; Makhatadze George I. | Zendy; Tereshko Valentina | Zendy; Kossiakoff Anthony A. | Zendy; Kent Stephen B. | Zendy

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Total Chemical Synthesis and X‐ray Crystal Structure of a Protein Diastereomer: [ D ‐Gln 35]Ubiquitin

Author(s) -

Bang Duhee,

Makhatadze George I.,

Tereshko Valentina,

Kossiakoff Anthony A.,

Kent Stephen B.

Publication year - 2005

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200463040

Subject(s) - diastereomer , ubiquitin , native chemical ligation , chemistry , similarity (geometry) , stereochemistry , chemical synthesis , computer science , biochemistry , artificial intelligence , in vitro , image (mathematics) , gene

Striking similarity : An efficient synthetic route to native ubiquitin and its diastereomer [ D ‐Gln 35]ubiquitin was realized by combining a one‐pot native chemical ligation process with protein desulfurization. High‐resolution X‐ray crystallographic studies of the protein diastereomer (see picture) revealed a striking conservation of molecular structure.

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