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Total Chemical Synthesis and X‐ray Crystal Structure of a Protein Diastereomer: [ D ‐Gln 35]Ubiquitin
Author(s) -
Bang Duhee,
Makhatadze George I.,
Tereshko Valentina,
Kossiakoff Anthony A.,
Kent Stephen B.
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200463040
Subject(s) - diastereomer , ubiquitin , native chemical ligation , chemistry , similarity (geometry) , stereochemistry , chemical synthesis , computer science , biochemistry , artificial intelligence , in vitro , image (mathematics) , gene
Striking similarity : An efficient synthetic route to native ubiquitin and its diastereomer [ D ‐Gln 35]ubiquitin was realized by combining a one‐pot native chemical ligation process with protein desulfurization. High‐resolution X‐ray crystallographic studies of the protein diastereomer (see picture) revealed a striking conservation of molecular structure.