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Stable Reagents for the Generation of N‐Centered Radicals: Hydroamination of Norbornene
Author(s) -
Kemper Jens,
Studer Armido
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200463032
Subject(s) - hydroamination , reagent , radical , norbornene , chemistry , combinatorial chemistry , organic chemistry , medicinal chemistry , catalysis , copolymer , polymer
Radical transfer hydroaminations have been achieved with 3‐aminated 1,4‐cyclohexadienes rather than transition‐metal reagents (see scheme; DTBP=di‐ tert‐ butylperoxide). These functionalized cyclohexadienes are efficient N‐radical precursors. Moreover, they are stable and readily prepared, and radical generation occurs under neutral conditions.