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Engineering a 2D Protein–DNA Crystal
Author(s) -
Malo Jonathan,
Mitchell James C.,
VénienBryan Catherine,
Harris J. Robin,
Wille Holger,
Sherratt David J.,
Turberfield Andrew J.
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200463027
Subject(s) - dna , oligonucleotide , crystallography , symmetry (geometry) , crystal structure , computational biology , lattice (music) , computer science , physics , biology , chemistry , genetics , mathematics , geometry , acoustics
Weaving with DNA : A DNA‐binding protein was used to control the structure of a self‐assembled 2D crystal. In the absence of protein, four oligonucleotides hybridize to form a Kagome lattice of interwoven double helices with p 3 symmetry (see image). Addition of protein RuvA during assembly changes the symmetry and connectivity to give a DNA–protein crystal with an approximately square unit cell.