Premium
Engineering a 2D Protein–DNA Crystal
Author(s) -
Malo Jonathan,
Mitchell James C.,
VénienBryan Catherine,
Harris J. Robin,
Wille Holger,
Sherratt David J.,
Turberfield Andrew J.
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200463027
Subject(s) - dna , oligonucleotide , crystallography , symmetry (geometry) , crystal structure , computational biology , lattice (music) , computer science , physics , biology , chemistry , genetics , mathematics , geometry , acoustics
Weaving with DNA : A DNA‐binding protein was used to control the structure of a self‐assembled 2D crystal. In the absence of protein, four oligonucleotides hybridize to form a Kagome lattice of interwoven double helices with p 3 symmetry (see image). Addition of protein RuvA during assembly changes the symmetry and connectivity to give a DNA–protein crystal with an approximately square unit cell.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom