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Concomitant Monoreduction and Hydrogenation of Unsaturated Cyclic Imides to Lactams Catalyzed by Ruthenium Compounds
Author(s) -
Aoun Rimane,
Renaud JeanLuc,
Dixneuf Pierre H.,
Bruneau Christian
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200462996
Subject(s) - ruthenium , catalysis , reagent , chemistry , solvent , asymmetric hydrogenation , transformation (genetics) , medicinal chemistry , organic chemistry , combinatorial chemistry , enantioselective synthesis , biochemistry , gene
One for two : [Ru 4 H 6 ( p ‐cymene) 4 ]Cl 2 and [RuCl 2 ( p ‐cymene)] 2 , [Ru], are efficient catalyst precursors for the selective transformation of cyclic imides into saturated lactams (see scheme). The catalytic systems operate with the same reagent (H 2 ) to perform two transformations, namely, monoreduction of the carbonyl groups and hydrogenation of CC bonds, with the release only of water, which is the solvent of the reaction.