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Highly Enantioselective One‐Pot, Three‐Component Imino‐Reformatsky Reaction
Author(s) -
Cozzi Pier Giorgio,
Rivalta Eleonora
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200462757
Subject(s) - enantioselective synthesis , reformatsky reaction , component (thermodynamics) , scope (computer science) , combinatorial chemistry , chemistry , catalysis , organic chemistry , computer science , physics , thermodynamics , programming language
A key to molecular diversity is the preparation of new frameworks in multicomponent condensations of three or more reactants. A new highly enantioselective one‐pot, three‐component, nickel‐catalyzed, imino‐Reformatsky reaction affords β‐amino esters with 64–92 % ee (see scheme). The simplicity and broad scope of our method provide a practical access to useful building blocks.