Highly Enantioselective One‐Pot, Three‐Component Imino‐Reformatsky Reaction | Zendy

Cozzi Pier Giorgio | Zendy; Rivalta Eleonora | Zendy

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Highly Enantioselective One‐Pot, Three‐Component Imino‐Reformatsky Reaction

Author(s) -

Cozzi Pier Giorgio,

Rivalta Eleonora

Publication year - 2005

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200462757

Subject(s) - enantioselective synthesis , reformatsky reaction , component (thermodynamics) , scope (computer science) , combinatorial chemistry , chemistry , catalysis , organic chemistry , computer science , physics , thermodynamics , programming language

A key to molecular diversity is the preparation of new frameworks in multicomponent condensations of three or more reactants. A new highly enantioselective one‐pot, three‐component, nickel‐catalyzed, imino‐Reformatsky reaction affords β‐amino esters with 64–92 % ee (see scheme). The simplicity and broad scope of our method provide a practical access to useful building blocks.

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