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Fabrication of Chemical Microarrays by Efficient Immobilization of Hydrazide‐Linked Substances on Epoxide‐Coated Glass Surfaces
Author(s) -
Lee Myungryul,
Shin Injae
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200462720
Subject(s) - hydrazide , dna microarray , molecule , fabrication , combinatorial chemistry , epoxide , nanotechnology , chemistry , small molecule , chemical modification , materials science , organic chemistry , biochemistry , catalysis , gene , medicine , gene expression , alternative medicine , pathology
Fixed to the spot : A new, efficient, and simple immobilization technique for the construction of chemical microarrays has been developed. This technique is applicable to the site‐selective attachment of diverse substances, including small molecules, carbohydrates, and peptides, to glass slides (see picture). The chemical microarrays fabricated by using this method were applied to screening peptide and small‐molecule binding to proteins.