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Drastic Effect of a Single Base Difference between Human and Tetrahymena Telomere Sequences on Their Structures under Molecular Crowding Conditions
Author(s) -
Miyoshi Daisuke,
Karimata Hisae,
Sugimoto Naoki
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200462667
Subject(s) - telomere , tetrahymena , dna , base pair , function (biology) , biology , genetics , biophysics , chemistry , computational biology
Making a difference : Tetrahymena telomere sequences form well‐ordered G‐wires in the presence of cosolutes, whereas human telomere sequences remain as compact G‐quadruplexes (see picture). A single base difference in telomere sequences therefore can affect telomere function under cell‐like conditions. The G‐wire structure may be useful in the design of DNA nanomaterials.