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Synthesis of Medium‐Ring and Iodinated Biaryl Compounds by Organocuprate Oxidation
Author(s) -
Surry David S.,
Su Xianbin,
Fox David J.,
Franckevicius Vilius,
Macdonald Simon J. F.,
Spring David R.
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200462642
Subject(s) - ring (chemistry) , chemistry , banquet , scheme (mathematics) , core (optical fiber) , combinatorial chemistry , computer science , organic chemistry , philosophy , mathematics , telecommunications , theology , mathematical analysis
A biaryl banquet! Biphenyls with four ortho substituents, heteroaromatic compounds, iodinated biaryls, and medium rings containing biaryls are all readily synthesized by organocuprate oxidation. The utility of this new methodology is illustrated by the efficient synthesis of the medium‐ring core of sanguiin H‐5 (see scheme).