Premium
Axial Coordination of Carboxylate Activates the Non‐heme Fe IV O Unit
Author(s) -
Rohde JanUwe,
Que Lawrence
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200462631
Subject(s) - carboxylate , reactivity (psychology) , chemistry , heme , group (periodic table) , coordination complex , stereochemistry , unit (ring theory) , crystallography , medicinal chemistry , enzyme , metal , biochemistry , organic chemistry , medicine , alternative medicine , pathology , mathematics education , mathematics
Enhancing reactivity : A common feature of non‐heme iron enzymes is the presence of carboxylate groups. An axial carboxylate group has been introduced trans to the oxo group of a non‐heme oxoiron( IV ) complex (see scheme). The coordination of carboxylate destabilizes the Fe IV O unit and activates it towards reaction with dihydroanthracene.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom