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Axial Coordination of Carboxylate Activates the Non‐heme Fe IV O Unit
Author(s) -
Rohde JanUwe,
Que Lawrence
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200462631
Subject(s) - carboxylate , reactivity (psychology) , chemistry , heme , group (periodic table) , coordination complex , stereochemistry , unit (ring theory) , crystallography , medicinal chemistry , enzyme , metal , biochemistry , organic chemistry , medicine , alternative medicine , pathology , mathematics education , mathematics
Enhancing reactivity : A common feature of non‐heme iron enzymes is the presence of carboxylate groups. An axial carboxylate group has been introduced trans to the oxo group of a non‐heme oxoiron( IV ) complex (see scheme). The coordination of carboxylate destabilizes the Fe IV O unit and activates it towards reaction with dihydroanthracene.