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The Influence of Mixtures of Monodentate Achiral Ligands on the Regioselectivity of Transition‐Metal‐Catalyzed Hydroformylation
Author(s) -
Reetz Manfred T.,
Li Xiaoguang
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200462613
Subject(s) - hydroformylation , regioselectivity , triphenylphosphine , denticity , ligand (biochemistry) , catalysis , chemistry , transition metal , rhodium , metal , medicinal chemistry , stereochemistry , organic chemistry , receptor , biochemistry
1+1≠2 : The mixture of triphenylphosphine and phosphinine 1 with [Rh(acac)(CO) 2 ] forms a hydroformylation catalyst that effects the preferential formation of the branched product, even though each ligand alone mediates the opposite regioselectivity. Similar effects were observed for a series of other ligand combinations.