Mixtures of Configurationally Stable and Fluxional Atropisomeric Monodentate P Ligands in Asymmetric Rh‐Catalyzed Olefin Hydrogenation | Zendy

Reetz Manfred T. | Zendy; Li Xiaoguang | Zendy

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Mixtures of Configurationally Stable and Fluxional Atropisomeric Monodentate P Ligands in Asymmetric Rh‐Catalyzed Olefin Hydrogenation

Author(s) -

Reetz Manfred T.,

Li Xiaoguang

Publication year - 2005

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200462612

Subject(s) - denticity , chemistry , olefin fiber , catalysis , ligand (biochemistry) , asymmetric hydrogenation , medicinal chemistry , stereochemistry , organic chemistry , enantioselective synthesis , crystal structure , receptor , biochemistry

Mixed (pre)catalysts such as 1 arise when [Rh(cod) 2 ]BF 4 is combined with a 1:1 mixture of a BINOL‐derived monodentate phosphonite or phosphite ligand and a configurationally fluxional atropisomeric phosphite with a biphenol backbone. These systems provide excellent results for the Rh‐catalyzed asymmetric hydrogenation of β‐acylamino acrylates. BINOL=2,2′‐dihydroxy‐1,1′‐binaphthyl; cod=cycloocta‐1,5‐diene.

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