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Synthesis of Functionalized Salicylate Esters and Amides by Photochemical Acylation
Author(s) -
Soltani Omid,
De Brabander Jef K.
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200462577
Subject(s) - acylation , chemistry , nucleophile , steric effects , combinatorial chemistry , organic chemistry , functional group , salicylic acid , catalysis , biochemistry , polymer
Functionalized salicylates in a flash : Photolysis of functionalized benzodioxinones in the presence of alcohols or amines is a powerful method for the synthesis of sterically hindered salicylic esters and amides (see scheme). This reaction tolerates a broad range of functional groups and efficiently engages a wide range of acylation substrates, including sterically hindered nucleophiles that are inert to other acylation methods.