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Tunable Imaging of Cells Labeled with MRI‐PARACEST Agents
Author(s) -
Aime Silvio,
Carrera Carla,
Delli Castelli Daniela,
Geninatti Crich Simonetta,
Terreno Enzo
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200462566
Subject(s) - irradiation , nuclear magnetic resonance , paramagnetism , chemistry , contrast (vision) , mri contrast agent , magnetic resonance imaging , nuclear medicine , materials science , medicine , optics , physics , radiology , quantum mechanics , nuclear physics
Cell‐tracking experiments by MRI are possible with a novel class of Tb and Eu paramagnetic imaging agents, with which contrast is generated upon irradiation at a specific frequency (see picture). Middle: A) unlabeled; B) Tb‐labeled; C) Eu‐labeled; D) Tb‐ and Eu‐labeled cells. Left: irradiation at ±180 kHz (Tb‐agent‐specific). Right: irradiation at ±15 kHz (Eu‐agent‐specific).