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A Small‐Molecule Agonist of the Wnt Signaling Pathway
Author(s) -
Liu Jun,
Wu Xu,
Mitchell Brian,
Kintner Chris,
Ding Sheng,
Schultz Peter G.
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200462552
Subject(s) - wnt signaling pathway , xenopus , agonist , ligand (biochemistry) , pyrimidine , computational biology , small molecule , biology , chemistry , microbiology and biotechnology , signal transduction , receptor , stereochemistry , biochemistry , gene
A new tool for developmental biology : A screen of combinatorial chemical libraries identified the 2‐amino‐4,6‐disubstituted pyrimidine 1 as a dose‐dependent agonist of Wnt signaling. Tadpoles that developed from embryos treated with 1 had substantial head defects (see right‐hand image; left=control). Compound 1 appears to mimic the effects of a Wnt ligand in a Xenopus model and may be a useful tool in the study of physiological processes that involve the Wnt pathway.