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Switching on a Signaling Pathway with an Organoruthenium Complex
Author(s) -
Williams Douglas S.,
Atilla G. Ekin,
Bregman Howard,
Arzoumanian Arpine,
Klein Peter S.,
Meggers Eric
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200462501
Subject(s) - wnt signaling pathway , xenopus , signal transduction , ruthenium , phenotype , chemistry , microbiology and biotechnology , computational biology , world wide web , biology , biochemistry , computer science , gene , catalysis
Like an organic molecule! A chemically inert ruthenium complex acts as a metallopharmaceutic inhibitor of the protein kinase GSK‐3 by targeting its ATP‐binding site. It is shown to switch on the Wnt signal transduction pathway inside living cells and in Xenopus embryos, which developed a hyperdorsalized phenotype (see picture, top; bottom: control specimen) on administration of the complex.